Mass Spectrometry

The authors describe the in-line moisture measurement of a pharmaceutical granulation of lactose, microcrystalline cellulose, and crospovidone in a fluid bed granulator-dryer using top sprayed granulating liquid. A near-infrared (NIR) prediction model was developed for moisture on spectra collected during a calibration run. Subsequent granulations were analyzed for moisture content real-time throughout the granulation and drying process using the NIR process instrument.

What does the accelerating adoption of PAT-based approaches to pharmaceutical manufacturing mean for the makers and users of spectroscopic systems?

NIR-CI adds a completely new dimension to conventional NIR spectroscopy.

Mass spectrometry systems have specific vacuum requirements. New developments in oil-free, or dry, primary vacuum pumps have been introduced recently and are discussed in this article with respect to capacity, throughput, and specific pumping requirements for process gases.

Encoded photometric technology has the ability to address the demands of modern process applications, including those of the PAT initiative.

This article discusses the key components of a typical liquid sample introduction system for inductively coupled plasma spectroscopy, and offers troubleshooting tips for problems commonly encountered by practitioners.

Through symposia, posters, and workshops, representatives from industry and academia addressed a broad range of technology and implementation issues that are beginning to change the landscape of modern spectroscopy.

The authors at how linearity considerations fit into the broader scheme of calibration theory, and discuss methods for testing data for non-linearity.

This paper describes how analysts at an environmental and geochemical laboratory utilize dynamic reaction cell ICP-MS technology to study the transport and deposition of important trace metals from rainwater.

The author provides a brief historical and technological review of different types of telescopes, and how they were developed and improved.

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This article summarizes recent efforts by the Duquesne University Center for Pharmaceutical Technology to develop and validate a PAT method using NIR spectroscopy for the on-line prediction of tablet hardness and active pharmaceutical ingredient content.

Recent advances in thin-film filter technology have enabled dramatic improvements in the performance of filters for laser-based analytical instrumentation.

The authors show that high resolution 1H nuclear magnetic resonance (NMR) spectroscopy can be used to study biofilm metabolism under environmentally relevant conditions in a minimally invasive way.

Recent advances in thin-film filter technology have enabled dramatic improvements in the performance of filters for laser-based analytical instrumentation.

This article summarizes recent efforts by the Duquesne University Center for Pharmaceutical Technology to develop and validate a PAT method using NIR spectroscopy for the on-line prediction of tablet hardness and active pharmaceutical ingredient content.

Recent advances in thin-film filter technology have enabled dramatic improvements in the performance of filters for laser-based analytical instrumentation.

Howard Mark and Jerry Workman revisit their recent series on derivatives, marking their 100th column contribution to Spectroscopy.

As part of dyslexia study, Wake Forest University researchers develop a software program that integrates data from different imaging modalities.

Mass spectrometrists have been measuring masses in the ultrasmall world for the past 50 years. However, a sense of our own accomplishments does not derive from the same perspective linking ultrasmall masses to the normal-mass world.