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high quality Galvanized steel pipe or Aluminum and chrome stainless pipes in stack waiting for shipment in warehouse | Image Credit: © kasarp -
Stable Variable Selection Method and Comparison for Quantitative Analysis of Steels Using Laser-Induced Breakdown Spectroscopy

June 27th 2024

In this work, a stable variable selection method based on variable stability correction (VSC) and modified iterative predictor weighting-partial least squares (mIPW-PLS) is proposed for the quantitative analysis of steel samples by laser-induced breakdown spectroscopy (LIBS).

Microscopic view of organic substance, bacteria, virus or cancer cell, macro on pink purple background | Image Credit: © Renata Hamuda -
Effect of Tissue Optical Properties on the Fluorescence of BODIPY Derivative as a Photosensitizer for Photodynamic Therapy

May 30th 2024

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Optical Constants of Mixed Crude Oil in Visible Waveband Based on the Double-Thickness Transmittance Method

May 15th 2024

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Identification of Different Dairy Products Using Raman Spectroscopy Combined with Fused Lasso Distributionally Robust Logistic Regression

April 23rd 2024

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Developing Portable Raman Spectroscopy Methods for Identification of Raw Materials Used in Pharmaceutical Development and Manufacturing

February 1st 2017

Portable instrumentation for Raman spectroscopy has rapidly evolved over the last decade, where sample testing that once occurred in the laboratory is now executed in the field (e.g. warehouse).   Portable Raman spectroscopy is a powerful technique for the rapid identification of diversely sourced raw materials used in pharmaceutical processing.  In addition to portability; reduced cost, rapid data acquisition and ease of use make this powerful technique attractive and accessible to both expert spectroscopists and non-specialists.  In most cases, the method development can be easily accomplished in the laboratory after which the instrument and methods are transferred to field for sample analysis or warehouse areas for inspection of incoming raw material.  Qualitative Raman methods for identification of raw materials typically utilize spectral libraries for sample to standard comparison.  When developing Raman spectral libraries for raw material identification, great care is required when considering critical factors (e.g. instrument type, Raman capability, container type, container interference, background interference, material variability) that can potentially influence the identity of the material.  This paper discusses portable Raman techniques and approaches for raw material identification, as well as key considerations for developing and validating Raman spectral libraries.