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Simultaneous Determination of 50 Elements in Geochemical Samples by Low-Pressure Closed Digestion-ICP-MS

January 1st 2024

The article describes a method for geochemical sample analysis using polytetrafluoroethylene (PTFE) crucibles and ICP-MS, achieving detection limits below 0.2 μg/g and relative standard deviations ranging from 1.1% to 16.4%. The approach minimizes acid usage, prevents dust contamination, accurately determines volatile elements, and is deemed suitable for high-throughput laboratories with numerous samples and diverse elements to be tested.

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Hyperspectral Imaging Combined with Convolutional Neural Network for Rapid and Accurate Evaluation of Tilapia Fillet Freshness

December 8th 2023

3D image of Chrysene skeletal formula - molecular chemical structure of Benzophenanthrene isolated on white background | Image Credit: © kseniyaomega - stock.adobe.com.
Interacting Characteristics of Chrysene with Free DNA in vitro

December 1st 2023

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EDX and LIBS Studies on Gallstones Using Partial Least Squares Discriminant Analysis (PLS-DA)

October 1st 2023

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Detection of Acute Kidney Injury Induced by Gentamicin in a Rat Model by Aluminum-Foil-Assisted ATR-FT-IR Spectroscopy

September 1st 2023

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Developing Portable Raman Spectroscopy Methods for Identification of Raw Materials Used in Pharmaceutical Development and Manufacturing

February 1st 2017

Portable instrumentation for Raman spectroscopy has rapidly evolved over the last decade, where sample testing that once occurred in the laboratory is now executed in the field (e.g. warehouse).   Portable Raman spectroscopy is a powerful technique for the rapid identification of diversely sourced raw materials used in pharmaceutical processing.  In addition to portability; reduced cost, rapid data acquisition and ease of use make this powerful technique attractive and accessible to both expert spectroscopists and non-specialists.  In most cases, the method development can be easily accomplished in the laboratory after which the instrument and methods are transferred to field for sample analysis or warehouse areas for inspection of incoming raw material.  Qualitative Raman methods for identification of raw materials typically utilize spectral libraries for sample to standard comparison.  When developing Raman spectral libraries for raw material identification, great care is required when considering critical factors (e.g. instrument type, Raman capability, container type, container interference, background interference, material variability) that can potentially influence the identity of the material.  This paper discusses portable Raman techniques and approaches for raw material identification, as well as key considerations for developing and validating Raman spectral libraries.