Spectroscopy Interviews

By pursuing research focusing on a fundamental understanding of the physics and chemistry underlying ambient desorption/ionization–mass spectrometry (ADI-MS), Jake Shelley, the 2020 winner of the Emerging Leader in Atomic Spectroscopy award, has delved into the underlying science behind desorption and ionization phenomena as well as the issues associated with sample matrix effects inherent for plasma-based mass spectrometry.

Background correction is a critical part of any spectrometric analysis, but how much can you trust it? In this ebook, learn about traditional correction methods as well as a better way for background correction.

X-ray diffraction (XRD) techniques are often used to understand the nature of stacking of layers that form clay nanocrystals. But there are problems with these techniques that make applications difficult and often ambiguous. Dr. David Bish, Professor Emeritus at Indiana University (Bloomington, Indiana), and former students Dr. Hongji Yuan and Dr. Alberto Leonardi have been exploring ways to streamline and accelerate the process with a new matrix methodology as well as gaining more accurate results through the use of simulated profiles based on very large-scale atomistic models. We spoke to Dr. Bish about his group’s work in these areas and what these improvements can mean for the future of XRD modeling.

Christy L. Haynes, of the University of Minnesota (Minneapolis and Saint Paul, Minnesota), has been working with her research team to explore the use of a rapid and facile technique to empirically screen affinity agents of diverse compositions for all manner of targets. Here, she describes the advantages of using isothermal titration calorimetry (ITC) for screening of polymer affinity agents for use with surface-enhanced Raman scattering (SERS).

By combining Raman spectroscopy, imaging, and chemometrics, Ishan Barman of Johns Hopkins University, the 2019 winner of the Emerging Leader in Spectroscopy award, develops novel approaches in which structural and molecular data converge to provide fresh insights into cancer, diabetes and an array of other diseases.

SERS is a method that is receiving new attention in the detection, analysis, and identification of both natural and artificial food colorants. Lili He, at the University of Massachusetts, Amherst, recently spoke to Spectroscopy about this important analytical work.

Spectroscopy can be difficult to carry out outside a controlled laboratory environment. Imagine, then, the hurdles that would accompany performing spectroscopy in the extreme conditions of deep space or the ocean floor. Mike Angel, a professor of chemistry at the University of South Carolina, has taken on those challenges, working on new types of instruments for remote and in- situ laser spectroscopy, with a focus on deep-ocean, planetary, and homeland security applications of deep ultraviolet Raman, and laser-induced breakdown spectroscopy to develop the tools necessary to work within these extreme environments.

In biology and medical research in areas such as the study of insulin, achieving greater temporal resolution and lower detection limits is critical. Christopher Easley, of Auburn University, and the winner of 2019 American Electrophoresis Society (AES) Mid-Career Award, is working to address this challenge.

Raman spectroscopy has been demonstrated as an analytical technique for characterizing disorder in two-dimensional (2D) crystalline material structures caused by the presence of defects (1). This disorder in 2D crystalline structures may be described from a dimensionality point of view, zero-dimensional (0D), or one-dimensional (1D) defects, expressed as points or lines, respectively. For characterization of the quantity of 0D and 1D defects respectively, two Raman measurement parameters are required as defect-induced activation of forbidden Raman modes, and defect-induced confinement of phonons. Professor Ado Jorio, of the Department of Physics at the Universidade Federal de Minas Gerais in Brazil, recently talked to us about his research in this field.

Laser induced breakdown spectroscopy (LIBS) and time-resolved two-dimensional LIBS have been applied as quantitative and qualitative analytical methods for multiple materials and matrices, from animal tissue, to archeological ceramics, to dairy products, to zeolite composition. We were recently able to interview Professor Jorge O. Cáceres, the Director of the Laser Chemistry Group in the Department of Analytical Chemistry at the Universidad Complutense de Madrid, in Spain, who is working with LIBS for new method development. He recently spoke to us about his most recent LIBS research.

Laser induced breakdown spectroscopy (LIBS) has been applied as quantitative and qualitative analytical method for a variety of matrices. A paper published in the journal Applied Spectroscopy in 2018 (1) was chosen by from the North American Society for LIBS (NASLIBS) and the Society for Applied Spectroscopy (SAS) as the best paper on the topic of LIBS. In this paper, a molten salt aerosol–laser-induced breakdown spectroscopy (LIBS) instrument was used to measure the uranium (U) content in a ternary UCl3–LiCl–KCl salt matrix to investigate the development of a near real-time analytical method. We spoke with Ammon Williams, the primary author of this paper, who is currently with the Idaho National Laboratory (INL), about this work.

Timothy J. Johnson and Tanya L. Myers, the 2019 winners of the Applied Spectroscopy William F. Meggers Award, have been exploring novel methods using infrared (IR) and visible reflectance spectroscopies for identification of target chemicals through derivation of the n and k optical constants. For their winning paper, Johnson and Myers created a spectroscopic library of 57 liquids for which they measured the complex refractive index, data that can be used for optical modeling and other purposes. They shared some of the details of their work with Spectroscopy.

Barry Wise, the president of Eigenvector Research, is a renowned expert in chemometrics. We recently spoke to him to get his thoughts and opinions on the latest developments in chemometrics for the analytical sciences.

SciX Award winner Benedikt Schwarz explains his groundbreaking work in portable infrared devices.

Javier Laserna has developed a technique for analyzing the composition of individual nanoparticles that is capable of detecting nanoparticles as the attogram level, by combining LIBS with optical trapping.

Raman spectroscopy is a versatile tool to identify and characterize the chemical and physical properties of graphene-based materials (1-4). Raman spectroscopy provides information on graphene structures for fundamental research and for practical device fabrication. Raman scattering demonstrates the first- and second-order modes in intrinsic graphene as well as the shear, layer-breathing, and the G and 2D modes of multilayer graphene. Professor Ping-Heng Tan from the State Key Laboratory of Superlattices and Microstructures at the Institute of Semiconductors at the Chinese Academy of Sciences is carrying out new research to advance the use of Raman analysis of these materials. We recently interviewed Tan about this work.

Significant progress is being made to harness the power of spectroscopy technique for medical research. An ongoing challenge, and area of development, in this effort, is to “see” more and more detail about biological activity, even within individual cells. Ji-Xin Cheng, a professor of biomedical engineering at Boston University, is advancing such work, by developing techniques like midinfrared photothermal (MIP) imaging and Raman spectromicroscopy. Cheng is the 2019 winner of the Ellis R. Lippincott Award, which is awarded annually by the Optical Society, the Coblentz Society, and the Society for Applied Spectroscopy, to an individual who has made significant contributions to the field of vibrational spectroscopy. Here, Cheng speaks to us about those techniques.

Recent advances in Raman spectroscopy, specifically using surface enhanced spatially offset resonance Raman spectroscopy (SESORRS), which is a combination of surface enhanced Raman scattering (SERS), and spatially offset Raman spectroscopy (SORS) are enabling noninvasive, real-time measurements of living tissue and multiple bacterial pathogens. In an interview with Karen Faulds, the 2019 recipient of the FACSS Charles Mann Award for Applied Raman Spectroscopy, we explore the latest developments in Raman spectroscopy for biomedical analysis applications. This interview is part of a series of interviews with the winners of awards presented at the SciX conference.

The 2019 recipient of the Clara Craver award, Xiaoyun (Shawn) Chen, is a senior research scientist working in the Core R&D Analytical Sciences department of the Dow Chemical Company. Chen, who will receive this award this fall at SciX 2019 in Palm Springs, California, recently spoke to Spectroscopy about his work.

Nick Stone of the University of Exeter explains why mid-infrared (mid-IR) spectroscopy is so valuable for spectral imaging in disease research and clinical diagnostics, and discusses his own recent work in this area.

Mohamad Sabsabi of the National Research Council of Canada explains the fundamentals of LIBS, its recent evolution, and its benefits and limitations, and offers advice for new users.

Advanced techniques in tissue engineering hold promise to those who suffer from damage to or degeneration of joint cartilage. But some challenges exist for tissue engineers to gain a better understanding of the development of these constructs and their mechanical properties. Nancy Pleshko, a professor of Bioengineering at Temple University (Philadelphia, Pennsylvania) has been studying the use of Fourier-transform–infrared imaging spectroscopy (FT-IRIS) as well as near-infrared (NIR) spectroscopy to explore the ways in which these techniques can aid in the development of replacement tissue. We spoke to her about her research and findings.

Laser-induced breakdown spectroscopy (LIBS) has seen significant expanded adoption in recent years, particularly in industrial applications where it can provide important advantages over other techniques. Mohamad Sabsabi, of the National Research Council of Canada, has been leading programs to research and implement the use of LIBS in mining and energy applications.

Lili He, an associate professor in the Department of Food Science at the University of Massachusetts, Amherst, focuses on developing and applying advanced analytical techniques to solve critical and emerging issues in food science. Recently, that focus has turned to using surface-enhanced Raman spectroscopy (SERS) in the detection, analysis, and identification of both natural and artificial food colorants. Dr. He recently spoke to Spectroscopy about that work.

As the use of nanoparticles in a wide range of applications continues to increase, the need for techniques to analyze these particles also increases. Javier Laserna of the University of Málaga, in Spain, has developed an approach to measure individual nanoparticles in air using optical trapping (OT) combined with laser-induced breakdown spectroscopy (LIBS). Laserna received the 2018 Lester W. Strock award for this development as well as his broader research on analytical methods and instrumentation using LIBS. He recently spoke to us about this work.