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Trace Element Analysis of Heavy Metals in Pharmaceutical Materials
February 1st 2010One of the most common product safety-related analytical tests in the pharmaceutical industry (often referred to as a Limit Test) is the quantification of heavy metals or inorganics in all materials within a pharmaceutical product.
Applications of 1064 nm Dispersive Raman Systems in Biofuel Research
February 1st 2010BaySpec, Inc. has developed a complete line of 1064 nm excitation, dispersive Raman systems that offer maximum reduction in fluorescence interference from biological samples and thus making them very useful tools for biofuel research.
Petrochemical Product and Process Control Using Rapid TD-NMR Technology
February 1st 2010TD-NMR (Time-Domain Nuclear Magnetic Resonance) is a powerful tool for the petrochemical industry, from exploration to refining, that examines materials at the molecular level to quantify physicochemical properties.
Diffuse Reflectance Spectroscopy Using a Handheld FTIR
September 1st 2009As has been previously discussed (1), FTIR spectroscopy is emerging as a technique that can be effectively used for applications and/or in locations that heretofore would be considered too demanding. The development of portable FTIRs, and more recently handheld FTIRs, is significant because it enables this powerful analytical technique to solve problems for a whole range of new applications, both in the laboratory, and out of the laboratory.
Polymer Analysis in Accordance with ASTM F2617-08 Using TOXEL and RoHS Calibration Standards
September 1st 2009This application note demonstrates the analysis of lead, cadmium, mercury, chromium, and bromine in polymers, compliant to ASTM F2617-08. The TOXEL and RoHS Calibration Standards were used to set up the calibration on Epsilon 5. The accuracy of the calibration is demonstrated by determination of European Reference Material (ERM) EC681k.
Chemometric Raman Imaging Data Analysis
September 1st 2009The development of advanced polymeric materials requires detailed information about the phase separation process on the nanometer scale. Confocal Raman microscopy contributes to the analysis of such materials by visualizing the distribution of individual components based on the unique Raman spectra for different polymeric materials. Using a confocal setup, polymer domains can be imaged three-dimensionally with a resolution down to 200 nm. As a Raman image typically consists of tens of thousands of spectra, a powerful data analysis software is essential in order to extract the relevant information. Hidden structures in the images should ideally be visualized automatically, ensuring an objective and consistent interpretation of the imaging data.
Analysis of Drug Eluting Stent Coating Solutions Using FT-NIR Spectroscopy
September 1st 2009A drug-eluting stent (DES) is an expandable metal alloy framework placed into narrowed coronary arteries that slowly releases a drug coating to treat atherosclerosis. Production of DES is a labor-intensive batch process that requires very tight control. Fourier Transform Near-InfraRed spectroscopy (FT-NIR) is an efficient technique to perform accurate quantification of the different components in DES coating solutions.
New Approach for Optimizing a Monoclonal Antibody Biotherapeutic in Different Formulations
September 1st 2009A prerequisite for a successful biotherapeutic formulation is one where the protein is stable and correctly folded. The new technique of dynamic multi-mode spectroscopy (DMS) was used to study the stability of a monoclonal antibody biotherapeutic formulated in acetate and lactate buffers. The samples were measured several times over a period of weeks and it became apparent that the antibody behaved differently as it aged in the two formulations, with the lactate formulation imparting greater robustness than the acetate.
Economical Maya2000 Pro Spectrometer Extends to VDUV
September 1st 2009Spectral measurements to 153 nm can be achieved easily and economically with the high-sensitivity Maya2000 Pro with Extra-Deep-UV Option. Nitrogen purging of the spectrometer helps to mitigate water and oxygen absorption in the vacuum ultraviolet.